An S1P Receptor Modulator Approved for UC1

Sphingosine 1-phosphate (S1P) signaling plays a role in the pathophysiology of inflammatory
conditions like UC2

S1P Lymphocyte Lymphoid
Organ
Efferent
Lymphatic
Vessel
Blood
Vessel

S1P is a signaling molecule that interacts with S1P receptors on lymphocytes.3

ZEPOSIA UC Mechanism of Action

Lymphocytes migrate from a low S1P concentration in lymphoid tissue to a high S1P concentration in the circulation and inflamed intestinal tissue.5-8,10

S1P
Receptor

Lymphocyte migration is guided by an S1P
concentration gradient to sites of inflammation.2,4-9

Lymphocyte S1P ZEPOSIA UC Mechanism of Action S1P
Receptor

S1P is a signaling molecule that interacts with S1P receptors on lymphocytes.3

Lymphoid
Organ
Efferent
Lymphatic
Vessel
Blood
Vessel
ZEPOSIA UC Mechanism of Action

Lymphocytes migrate from a low S1P concentration in lymphoid tissue to a high S1P concentration in the circulation and inflamed intestinal tissue.5-8,10

Lymphocyte migration is guided by an S1P concentration gradient to sites of inflammation.2,4-9

ZEPOSIA is a small
molecule that reversibly
sequesters lymphocytes
in lymphoid tissue1,11,12

The mechanism by which ZEPOSIA exerts therapeutic effects in UC is unknown but may involve the reduction of lymphocyte migration into the intestine.1

Lymphoid
Organ
Efferent
Lymphatic
Vessel
Blood
Vessel

ZEPOSIA
Small Molecule12

ZEPOSIA binds
with high affinity
to S1P receptors
1 and 5.1,11,13a

MOA of ZEPOSIA UC

This blocks the capacity of lymphocytes to egress from lymphoid tissue, reducing the number of lymphocytes in the peripheral circulation.1

ZEPOSIA induces a sustained
internalization of S1P1 receptors.11,13

The mechanism by which ZEPOSIA exerts therapeutic effects in UC is unknown but may involve the reduction of lymphocyte migration into the intestine.1

ZEPOSIA
Small Molecule12

MOA of ZEPOSIA UC

ZEPOSIA binds
with high affinity
to S1P receptors
1 and 5.1,11,13a

Lymphoid
Organ
Efferent
Lymphatic
Vessel
Blood
Vessel
MOA of ZEPOSIA UC

This blocks the capacity of lymphocytes to egress from lymphoid tissue, reducing the number of lymphocytes in the peripheral circulation.1

ZEPOSIA induces a sustained
internalization of S1P1 receptors.11,13

Artist rendering for illustrative purposes

aZEPOSIA has minimal or no activity on SIP receptors 2-4.1

S1P=sphingosine 1-phosphate; UC=ulcerative colitis.

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