What’s Next for Patients With Moderate-to-Severe UC When Conventionalsa Aren’t Enough?

5-ASA maintenance therapy may not deliver the relief that patients need1

graphic depicting 7 out of 10 patients who received 5-ASA therapy

7 out of 10 patients receiving 5-ASA therapy failed to achieve remission1b

Steroids can provide short-term relief, but patients may become over-reliant2,3

Steroids can provide short-term relief, but patients may become over-reliant

More than 1/3 of patients who filled steroids after UC diagnosis became steroid dependent2,3c

Even though advanced therapy may be recommended, patients often refuse biologics4

Stop icon

Almost 30% of patients deny or delay therapy due to concerns with biologics4d

After conventionals, start
The only oral advanced therapy that can be used before biologics5-7

A non-biologic, small molecule with once-daily oral dosing.5

  • aIncludes 5-ASAs and corticosteroids.
  • bIn a systematic review of 11 RCTs published from 1987-2014, 71% (n=1107/1550) of patients with mild to moderate UC failed to enter clinical remission while taking 5-ASAs.1
  • cIn a retrospective cohort study from 2001-2011 of newly diagnosed patients with UC (N=464, 92% male) who received CS for a flare, 38% (n=175) of patients who required further CS therapy met criteria for CS dependency.2
  • dAs reported in the multinational 2019 GAPPS survey of patients with UC (n=1030), 78% of which self-reported as having moderate/severe disease. Data is representative of a subset of patients (n=319) who responded to the question regarding opting against IBD treatment. The IBD GAPPS survey was conducted by Adelphi Real World and supported by Bristol-Myers Squibb Company.4

5-ASAs=5 aminosalicylic acids; CS=corticosteroids; IBD=inflammatory bowel disease; RCTs=randomized controlled trials; UC=ulcerative colitis.

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