One capsule, once a day, from the start with minimal pre-initiation requirements1
ZEPOSIA 7-DAY TITRATION SCHEDULE1
Dosing Considerations
An up-titration schedule should be used to reach the maintenance dose, as a transient decrease in heart rate and AV conduction delays may occur
ZEPOSIA may be taken with or without food
If a dose is missed within the first 2 weeks of treatment, reinitiate treatment using the titration regimen
If a dose is missed after the first 2 weeks of treatment, continue with the treatment as planned
Starter Kit
The ZEPOSIA 7-day Starter Pack is designed to make the titration easier to follow1
Eligible patients enrolled in ZEPOSIA 360 Support™, who have been cleared to begin treatment, and who have not received a sample from their provider, may be provided a Starter Kit that includes a 7-day Starter Pack and a 21-day supply of ZEPOSIA
Full Prescribing Information for ZEPOSIA Has
NO Genetic Testing
NO Ophthalmic Testing for Most Patients1a
NO First-Dose Observation Required
Minimal Pre-Initiation Requirements
Before Initiating Treatment With ZEPOSIA...
Obtain a CBC (within 6 months or after discontinuation of prior MS therapy), including lymphocyte count
Obtain an ECG to determine whether preexisting conduction abnormalities are present
Obtain transaminase and bilirubin levels (within 6 months)
Evaluate current and prior medications1
Patients without a confirmed history of VZV or without documented VZV vaccination should be tested for antibodies. If VZV or other live attenuated immunizations are required, administer at least 1 month prior to initiation1
aDiabetes mellitus and uveitis increase the risk of macular edema; patients with a history of these conditions should have an ophthalmic evaluation of the fundus, including the macula, prior to treatment initiation. A prompt ophthalmic evaluation is recommended if there is any change in vision while taking ZEPOSIA.1